Improving Antibacterial Efficiency of Curcumin in Magnetic Polymeric Nanocomposites

Abstract In recent years, resistance to chemical antibiotics, as well their side effects, has caused a necessity utilize natural substances and herbal components with antibacterial effects. Curcumin, the major substance of Curcuma longa ’s rhizome, was used an agent since ancient times. This work aimed formulate novel nanocomposite for delivery curcumin overcome orthodox drugs against bacteria improve its efficacy. To fabricate targeting nanocomposites, first, Fe 3 O 4 nanoparticles were synthesized followed by coating obtained using sodium alginate containing curcumin. A 2 factorial design tailored predict optimum formulation nanocomposites. Characterization nanocomposites including particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, drug loading performed. The analyzed differential scanning calorimetry (DSC), electron microscopy (SEM), Fourier-transformed infrared spectroscopy (FT-IR), in vitro release study at different pHs. Finally, minimum inhibitory concentration (MIC) bactericidal (MBC) samples seven common determined. Results showed that optimized contained 400 nm particles PDI potentials 0.4 − 58 mV, respectively. 70% efficiency reduced MIC value times comparison pure also polymer concentrations can significantly affect efficiency. conclusion, current investigation demonstrated this magnetic be applied Graphical abstract